Retatrutide

Description

What is Retatrutide?

Retatrutide is a 39-amino-acid synthetic peptide engineered as a triple agonist of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCGR) receptors. Developed by Eli Lilly under the code LY3437943, it is currently one of the most extensively studied investigational peptides in metabolic research, with Phase 3 clinical trials underway. Unlike Tirzepatide, which activates two incretin receptors, Retatrutide adds glucagon receptor activity to the mechanism.

It is supplied by Revial Labs as a lyophilised (freeze-dried) powder for reconstitution in bacteriostatic water. All product is intended strictly for laboratory research use.

Areas of Research Investigation

Retatrutide’s triple-agonist mechanism has generated significant research interest, including:

• Incretin and glucagon pharmacology — studies of simultaneous activation of three receptor pathways (GCGR, GIPR, GLP-1R) and their downstream signalling.
• Metabolic regulation models — investigation of glucose homeostasis, insulin sensitivity, and hepatic fat metabolism in preclinical models.
• Energy expenditure research — studies of glucagon receptor activation and its effect on basal metabolic rate.
• Comparative incretin research — head-to-head preclinical studies against selective GLP-1 agonists and dual GIP/GLP-1 agonists such as Tirzepatide.

This is a summary of published research directions and should not be interpreted as claims about the compound’s effects in humans. Retatrutide is an investigational compound not approved by the MHRA, FDA, or any equivalent regulatory body. The product supplied by Revial Labs is intended solely for in vitro laboratory research and is not for human or veterinary use.

Product Specifications

• Compound: Retatrutide (LY3437943)
• CAS number: 2381089-83-2
• Molecular weight: 4731.33 g/mol
• Structure: 39-amino-acid linear peptide with GIP backbone, non-coded residues at positions 2, 13 and 20, and a C20 fatty diacid modification at Lys20 via a PEG2/gamma-glutamic acid linker
• Form: Lyophilised (freeze-dried) powder
• Purity: ≥99% (HPLC verified)
• Certificate of Analysis: Independently third-party tested. Batch-specific COA available on request.

Reconstitution

Retatrutide is typically reconstituted in bacteriostatic water for research purposes. Bacteriostatic water contains 0.9% benzyl alcohol, allowing storage of the reconstituted solution over several weeks under refrigeration.

For step-by-step guidance, see our article How to Reconstitute Research Peptides, or use our Peptide Reconstitution Calculator.

Storage and Handling

• Before reconstitution: Store at 2–8°C (refrigerator) for long-term storage. Short-term room-temperature storage is acceptable during shipping.
• After reconstitution: Store the solution at 2–8°C and use within four weeks.
• Avoid: Direct sunlight, freeze-thaw cycles, and repeated agitation.

Frequently Asked Questions

What is included with this product?

One sealed vial of lyophilised Retatrutide powder in the quantity selected. Bacteriostatic water, syringes, and alcohol swabs are sold separately — see our Starter Accessory Pack for a bundled option.

How pure is Revial Labs Retatrutide?

All Retatrutide supplied by Revial Labs is manufactured to ≥99% purity and independently verified by High-Performance Liquid Chromatography (HPLC). A batch-specific Certificate of Analysis is available on request.

What is the difference between Retatrutide and Tirzepatide?

Both are 39-amino-acid peptides with a GIP-based backbone and C20 fatty diacid modification, but they differ in receptor targets. Tirzepatide is a dual agonist at GIP and GLP-1 receptors, while Retatrutide is a triple agonist adding glucagon receptor activity. This third mechanism is the focus of much of the current research interest. See our Retatrutide research overview for more.

How is Retatrutide shipped?

Orders are dispatched via Royal Mail tracked delivery from the UK, typically within one working day. Peptides remain stable at ambient temperature during transit; refrigeration is recommended once received.

Is a Certificate of Analysis included?

A batch-specific COA verifying identity, purity, and mass spectrometry is available on request. Contact us with your order number and we will send the corresponding document.

Related Products

• Tirzepatide — dual GIP/GLP-1 receptor agonist
• Bacteriostatic Water — recommended solvent for reconstitution
• 1ml U100 Insulin Syringe
• Alcohol Swabs

Further Reading

• Retatrutide: What It Is and What It’s Known For
• How to Reconstitute Research Peptides
• Why Third-Party COA Testing Matters in Peptide Research

Research Use Only

All products supplied by Revial Labs are intended for in vitro laboratory research use only. Not for human or veterinary use, not for use in food, cosmetics, or supplements, and not for diagnostic or therapeutic purposes. All customers agree to use products in accordance with these terms.