MOTS-C 10mg

Description

What is MOTS-C?

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome — one of the first identified mitochondrial-derived peptides (MDPs) with signalling activity. Discovered in 2015 by researchers at the University of Southern California, MOTS-C has emerged as a compelling molecule in metabolic and mitochondrial research, particularly for its role in the AMPK signalling pathway and glucose homeostasis in preclinical models.

It is supplied by Revial Labs as a lyophilised (freeze-dried) powder for reconstitution in bacteriostatic water. All product is intended strictly for laboratory research use.

Areas of Research Investigation

Published research on MOTS-C has been conducted primarily in animal and cell-culture models. Areas of research investigation include:

• AMPK pathway signalling — investigation of AMP-activated protein kinase activation as a downstream effect of MOTS-C exposure.
• Glucose homeostasis models — studies of insulin sensitivity and glucose disposal in diet-induced obesity models.
• Mitochondrial biogenesis research — examination of MOTS-C’s role in mitochondrial function and biogenesis.
• Ageing research — studies of MOTS-C decline with age and its correlation with metabolic markers.
• Exercise mimetic research — preclinical studies of MOTS-C as an exercise-mimicking signal in skeletal muscle.

This is a summary of published research directions and should not be interpreted as claims about the compound’s effects in humans. MOTS-C is not approved by the MHRA, FDA, or any equivalent regulatory body for human or veterinary use.

Product Specifications

• Compound: MOTS-C (Mitochondrial ORF of the 12S rRNA-c)
• Molecular formula: C₁₀₀H₁₆₀N₂₆O₂₂S₂
• Molecular weight: 2174.61 g/mol
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Quantity: 10mg per vial
• Form: Lyophilised (freeze-dried) powder
• Purity: ≥99% (HPLC verified)
• Certificate of Analysis: Independently third-party tested. Batch-specific COA available on request.

Reconstitution

MOTS-C is typically reconstituted in bacteriostatic water for research purposes.

For step-by-step guidance, see our article How to Reconstitute Research Peptides, or use our Peptide Reconstitution Calculator.

Storage and Handling

• Before reconstitution: Store at 2–8°C (refrigerator) for long-term storage. Short-term room-temperature storage is acceptable during shipping.
• After reconstitution: Store the solution at 2–8°C and use within four weeks.
• Avoid: Direct sunlight, freeze-thaw cycles, and repeated agitation.

Frequently Asked Questions

What is included with this product?

One sealed vial containing 10mg of lyophilised MOTS-C powder. Bacteriostatic water, syringes, and alcohol swabs are sold separately — see our Starter Accessory Pack for a bundled option.

How pure is Revial Labs MOTS-C?

All MOTS-C supplied by Revial Labs is manufactured to ≥99% purity and independently verified by High-Performance Liquid Chromatography (HPLC). A batch-specific Certificate of Analysis is available on request.

What makes MOTS-C unusual as a peptide?

MOTS-C is unusual in that it is encoded within the mitochondrial genome rather than the nuclear genome, making it one of the first identified mitochondrial-derived peptides (MDPs) with distinct signalling activity. This origin has made it a particular focus of research into mitochondrial-nuclear communication.

How is MOTS-C shipped?

Orders are dispatched via Royal Mail tracked delivery from the UK, typically within one working day. Peptides remain stable at ambient temperature during transit; refrigeration is recommended once received.

Is a Certificate of Analysis included?

A batch-specific COA verifying identity, purity, and mass spectrometry is available on request. Contact us with your order number and we will send the corresponding document.

Related Products

• SLU-PP-332 — investigational ERR agonist studied in mitochondrial and metabolic research
• NAD+ — coenzyme central to mitochondrial energy metabolism
• Bacteriostatic Water — recommended solvent for reconstitution
• 1ml U100 Insulin Syringe
• Alcohol Swabs

Further Reading

• How to Reconstitute Research Peptides
• Why Third-Party COA Testing Matters in Peptide Research

Research Use Only

All products supplied by Revial Labs are intended for in vitro laboratory research use only. Not for human or veterinary use, not for use in food, cosmetics, or supplements, and not for diagnostic or therapeutic purposes. All customers agree to use products in accordance with these terms.